Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations
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چکیده
منابع مشابه
Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations.
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has emerged as a novel powerful MS methodology that has the ability to generate both molecular and spatial information within a tissue section. Application of this technology as a new type of biochemical lipid microscopy may lead to new discoveries of the lipid metabolism and biomarkers associated with area-specif...
متن کاملSpecific MALDI-MSI: Tag-Mass.
MALDI imaging as a molecular mass spectrometry imaging technique (MSI) can provide accurate information about molecular composition on a surface. The last decade of MSI development has brought the technology to clinical and biomedical applications as a complementary technique of MRI and other molecular imaging. Then, this IMS technique is used for endogenous and exogenous molecule detection in ...
متن کاملMALDI-MSI: biomarker discovery for radiation exposures
Once outside of the Earth’s atmosphere astronauts are exposed to two main types of radiation, galactic cosmic rays (GCR) and solar energetic particles. GCRs consist of high energy, charged nuclei of elements ranging from H (hydrogen) to Fe (iron). High energy, charged nuclei of H (protons) are the major component of GCRs whereas approximately 1% of GCRs are larger ions with charges greater than...
متن کاملMALDI imaging MS of phospholipids in the mouse lung Karin
Journal of Lipid Research Volume 52, 2011 1551 Copyright © 2011 by the American Society for Biochemistry and Molecular Biology, Inc. that interfere with cysteinyl-leukotriene production are frequently used in treating asthma ( 6 ). These lipid mediators are derived from the enzymatic hydrolysis of arachidonatecontaining phospholipids, probably a phospholipase A 2 , and subsequent metabolism of ...
متن کاملMALDI imaging MS of phospholipids in the mouse lung.
Lipid mediators are important in lung biochemistry and are derived from the enzymatic oxidation of arachidonic and docosahexaenoic acids, which are PUFAs that are present in phospholipids in cell membranes. In this study, MALDI imaging MS was used to determine the localization of arachidonate- and docosahexaenoate-containing phospholipids in mouse lung. These PUFA-containing phospholipids were ...
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ژورنال
عنوان ژورنال: Chemistry and Physics of Lipids
سال: 2012
ISSN: 0009-3084
DOI: 10.1016/j.chemphyslip.2012.06.001